Bergqvist S., Croy C.H., Kjaergaard M., Huxford T., Ghosh G. & Komives E.A. (2006). Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J. Mol. Biol. 360 421-434. PubMed

Hansen S.B., Sulzenbacher G., Huxford T., Marchot P., Taylor, P.W. & Bourne, Y. (2005). Structures of Aplysia AChBP complexes with agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J. 24 3635-3646. PubMed

Hughes C.A., Bergqvist S., Huxford T., Ghosh G. & Komives E.A. (2004). Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci. 13 1767-1777. PubMed

Malek S., Huang D.-B., Chen Y., Huxford T., Ghosh S. & Ghosh G. (2003). X-ray crystal structure of an IkappaBbeta/NF-kappaB p65 homodimer complex. J. Biol. Chem. 278 23094-23100. PubMed

Huxford T., Mishler D., Phelps C.B., Chen Y., Sengchanthalangsy L.L., Reeves R., Hughes C.A., Komives E.A. & Ghosh G. (2002). Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation. J. Mol. Biol. 324 587-597. PubMed

Malek S., Chen Y., Huxford T. & Ghosh G. (2001). IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells. J. Biol. Chem. 276 45225-45235. PubMed

Huxford T., Malek S., & Ghosh G. (2000). Preparation and crystallization of dynamic NF-kappaB/IkappaB complexes. J. Biol. Chem. 275 32800-32806. PubMed

Phelps C., Sengchanthalangsy L.L., Huxford T. & Ghosh G. (2000). Mechanism of IkappaBalpha binding to NF-kappaB dimers. J. Biol. Chem. 275 29840-29846. PubMed

Huxford T., Huang D.-B., Malek S. & Ghosh G. (1998). The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell 95 759-770. PubMed

Malek S., Huxford T. & Ghosh G. (1998). IkappaBalpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB. J. Biol. Chem. 273 25427-25435. PubMed

Huang D.-B., Huxford T., Chen Y.-Q. & Ghosh G. (1997). The role of DNA in the mechanism of NF-kappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits. Structure 5 1427-1436. PubMed

Lamb J.D., Huxford T. & Czirr K.B. (1996). Capillary electrophoresis of anions in an untreated polypropylene hollow fiber. J. Chromatogr. A 739 373-378. ScienceDirect

 

Review Articles

Huxford T. & Ghosh G. (2005). Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. Methods Enzymol. 407 527-534. PubMed

Ghosh G., Huang D.-B.& Huxford T. (2004) Molecular mimicry of the NF-kappaB DNA target site by a selected RNA aptamer. Curr. Opin. Struct. Biol. 14 21-27. PubMed

Huxford T. & Ghosh,G. (2002). IkappaB proteins. In, Wiley Encyclopedia of Molecular Medicine, John Wiley & Sons, Inc. 1712-1716. Wiley

Huxford T., Malek S. & Ghosh G. (1999). Structure and mechanism in NF-kappaB/IkappaB signaling. Cold Spring Harbor Symp. Quant. Biol. 64 533-540. PubMed

Ghosh G., Huang D.-B. & Huxford T. (1999). Structural insights into NF-kappaB/IkappaB singaling. Gene Therapy and Molecular Biology 5 75-82. GT&MB

 

Book Chapters

Moorthy A.K., Huxford T. and Ghosh G. (2007) Structural aspects of NF-kappaB and IkappaB proteins In, Handbook of transcription factor NF-kappaB. Edited by Sankar Ghosh. Taylor and Francis CRC Press, Boca Raton, Florida 9-24. CRC

Huxford T. & Ghosh G. (2006). Structural analysis of NF-kappaB and IkappaB proteins. In, NF-kappaB/Rel Transcription Factor Family. Edited by Hsiou-Chi Liou: Landes Bioscience, Georgetown, Texas 1-11. Landes Bioscience

Huxford T., Moorthy A.K. and Ghosh G. (2006) kappaB-Ras: a small GTPase that influences NF-kappaB signaling. In, RAS Family GTPases. Protein and Cell Regulation series, Volume 4. Edited by Channing J. Der. Springer Science, Dordecht, The Netherlands 341-352. Amazon

Huxford T. & Ghosh, G. (2003). The structural biology of NF-kappaB. In, Nuclear Factor kappaB: Regulation and Role in Disease. Edited by Beyaert R: Klüwer publishers, Netherlands 179-200. Amazon