Taking a vacation is particularly important for spouses, who as I mentioned, often find themselves with increased professional and personal responsibilities when their mate falls ill.
You need to ask others from help, and take it when offered.
Use professional respite care - get over the notion that you are the only person who can take care of your mate properly.
Redefine some things as optional - you do not have to have polished silver, or even a spotless house - prioritize - what’s really important to your family?
Take a break from each other - I know this seems harsh, but it’s necessary. If you start feeling angry, resentful, ordered around - it’s time for a break, or a change of environment
Go out with friends, pursue hobbies - it’s okay to have fun
I’m not saying you won’t feel guilty, just try to keep the guilt at a dull roar