ENS 632   Physiological Chemistry of Exercise

 

Spring 2008

2:00-3:15 Tue/Thu

ENS Annex 106

 

Instructors:

Dr. Michael Buono

Dr. Fred Kolkhorst

 

ENS 307; 594-6823

ENS 311; 594-1924

 

mbuono@mail.sdsu.edu

fred.kolkhorst@sdsu.edu

office hours:

9:30-11 T, by appointment

9:30-11 MW, by appointment

 

Unit Objectives

 

Class Slides

Enzymes | Bioenergetics | Energy Substrate and Enzyme Kinetics | Glycolysis | Glycogenolysis | Muscle Glucose Uptake

Citric Acid Cycle | Mitochondria and Electron Transport Chain | Lipid Metabolism | Hepatic Glucose Regulation

Dietary Carbohydrate | Carbohydrate Feedings during Exercise | Endurance Training Adaptations

 

Skeletal Muscle Architecture | Introduction to Skeletal Muscle | Skeletal Muscle Structure

Excitation-Contraction | Skeletal Muscle Characteristics | Skeletal Muscle Fiber Types

  Muscle Plasticity | Muscle Fatigue | Exercise-Induced Muscle Damage and Repair

Hormonal Effects on Protein Turnover

 

 

 

Course syllabus

Date

Topic

ACSM text

Houston

Brooks et al.

Jan 22

Introduction; Review of bioenergetics

 

3

2

Jan 24

Energy substrates

 

3

3

Jan 29

Enzyme kinetics

 

2

3

Jan 31

Indirect calorimetry

 

 

4

Feb 5

Glycolysis; Glycogenolysis

 

5

5

Feb 7

Glucose uptake

 

5

5

Feb 12

Citric acid cycle;

 

4

6

Feb 14

Mitochondria and electron transport chain

 

4

6

Feb 19

Lipid metabolism

 

6

7

Feb 21

–continued

 

6

7

Feb 26

Hepatic glucose regulation

 

5

9

Feb 28

Dietary CHO and CHO feedings during exercise

 

 

28

Mar 4

Endurance training adaptations

 

 

28

Mar 6

–continued

 

 

 

Mar 11

EXAM 1 (part 1)

 

 

 

Mar 13

EXAM 1 (part 2)

 

 

 

Mar 18

Neural stimulation of skeletal muscle

3

 

 

Mar 20

Plasma membrane, ion channels and pumps

 

 

 

Apr 1

Skeletal muscle anatomy and sarcomere structure

5

 

 

Apr 3

Excitation-contraction

 

 

17

Apr 8

Contractile properties

5, 6

 

18

Apr 11

Muscle fiber types and polymorphism

5

 

17,18

Apr 15

Modulations of force output

5, 6

 

18

Apr 17

Muscle architecture

6

 

17

Apr 22

Muscular fatigue

8

 

 

Apr 24

–continued

8

 

17,18

Apr 29

Discussion on fatigue

 

 

19,20

May 1

Muscle plasticity

7

 

33

May 6

Exercise-induced muscular damage and regeneration

7

 

 

May 8

Transcription, protein synthesis, and degradation

30

8, 9

 

May 15

EXAM 2 (1:00 – 3:00)

 

 

 

 

Evaluation                                                                                                    Grading Scale

·         2 exams–100 points each                                                                        200 points        A  >  225

  • research paper                                                                                          50 points        B  =  200-224

TOTAL                                                                                                   250 points        C  =  175-199

 

 

Course materials

  • American College of Sports Medicine. ACSM’s Advanced Exercise Physiology.  Baltimore, MD:  Lippincott Williams & Wilkins, 2006. (required)
  • Houston, M.E. Biochemistry Primer for Exercise Science, 3rd edition. Champaign, IL: Human Kinetics, 2006 (required)
  • Brooks, G.A., T.D. Fahey, and K.M. Baldwin.  (2005). Exercise Physiology: Human Bioenergetics and Its Applications, 4th edition.  Boston: McGraw Hill. (optional)
  • general physiology textbook
  • course website (http://www-rohan.sdsu.edu/~ens632)
  • Blackboard (https://blackboard.sdsu.edu)

 

 

Research paper guidelines

The topic of the paper must have some relation to exercise biochemistry.  It must be on a topic that differs from your thesis and from any past research paper(s) in your graduate program.  Each student is to submit a 6-10 page research paper plus references and optional ancillary material.  Before you begin, Dr. Kolkhorst must approve your topic idea, which can be on any topic related to this course.  Tentative due dates are as follows:

  • submission of research paper topic                      March 18
  • research paper draft                                           April 11
  • research paper due                                            May 1

 

Begin the paper with an introduction and include a statement of the problem or purpose of the review.  At the end of the paper, include a short summary of the discussion as well as a conclusion and/or recommendation that relate to the purpose of the review.  Inclusion of supportive tables/figures is acceptable.  Work to make your arguments clear and concise, but well supported.  Reference all information that you use from other sources!  Avoid secondary sources; rather, use original articles as much as possible.  Include your reference list at the end of the paper.  Although not a requirement, following the APA style for formatting your paper is suggested.

 

 

Suggested web sites

Biochemistry of muscle contraction

 

Exercise-induced muscle damage and repair

 

Muscle architecture

 

Muscle physiology